Founded by American healthcare providers over 40 years ago, Integrative Therapeutics is a well-oved US wellness supplement brand. Every formula is backed by clinical research, manufactured following strict GMP guidelines and verified by independent third-party labs. Our Cortisol Manager and Berberine ease stress, boost sleep quality and support metabolic health. No unnecessary fillers or common allergens, totally safe for daily long-term use.

Clinician-curated supplements for you

Balancing your cortisol helps stop blood sugar spikes brought on by stress, while berberine keeps your metabolism running smoothly — the two work hand in hand to support your body.

    What exactly is cortisol?

    It's the main stress hormone made by your adrenal glands, people usually call it the stress hormone.

    In healthy people, cortisol rises and falls on a steady daily yde. It controls how well you handle stress, your energy levels, sleep schedule, mood balance, and even your metabolism.

    But constant anxiety, staying up late, and overworking throw your cortisol levels totally out of whack. That's what folks refer to as burnout or adrenal fatigue from chronic stress.

    Daily Tips for Balancing Your Cortisol

     

    Healing your hormones takes time

    You can't fix your endocrine system overnight. Stick with it for 30 to 45 days to fully stabilize your daily cortisol rhythm.

    Put your phones away before bed

    Blue light from screens ramps up cortisol levels and makes it even harder to fall asleep at night.

    Take small relaxing breaks throughout your day

    A 5-10 minute midday nap or slow deep breathing keeps excess cortisol from building up in your body.

    Important thing to know about our supplement

    It does not sedate your brain and is not a sleeping pill It simply helps your body get back its natural, healthy hormone cycle on its own.

    What Is Berberine?

    Berberine is a natural yellow alkaloid extracted from medicinal herbs such as coptis chinensis, phellodendron chinense and berberis soulieana. This potent herbal active compound has been utilized for thousands of years.

    Supported by abundant modern cinical research findings, it has tured into a top-selling dietary supplement within functional medicine communities throughout Europe and the United States

    Berberine fixes these key metabolic troubles

    Blood Sugar Imbalance

    Insulin resistance, sharp blood sugar spikes after meals & constant sugar cravings.

    High Lipids + Stubborn Belly Fat

    Elevated cholesterol/triglycerides, hard-to-lose visceral belly fat.

    Upset Digestive System

    Bloating, irregular bowel movements and unbalanced gut flora.

    Chronic Fatigue & Body Inflammation

    All-day tiredness, slow recovery from staying up late & mild fatty liver issues.

    Why Integrative Therapeutics?

    The short answer to that question is that our supplements are curated by practitioners, for practitioners. We meticulously develop high-quality products with science-based ingredients, providing expert guidance for their use-all to build practitioner-patient trust and compliance.

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    Certifications

    Our dedication to quality and safety has not gone unnoticed. Our facility boasts long-standing certifications and registrations from some of the most reputable and respected organizations, recognizing our world-class operations and track record of quality. We are proud that our onsite, state-of-the-art laboratory was awarded ISO 17025 accreditation in 2021, making Integrative Therapeutics one of the first internal labs in the dietary supplement industry to achieve such an honor. Accreditation to this internationally accepted standard provides formal recognition that our lab has proven its technical competence and operates a quality management system to provide reliable, accurate test results.

    • My doctor recommended this to manage stress hormone imbalance. It curbs afternoon stress slumps and eliminates midnight awakenings reliably for me.


      Paul Gardner

    • This supplement balanced my cortisol perfectly.Ifallasleep faster now, daytime anxiety faded away totally, totally worth continuous purchase.


      Michelle M.

    • Switched from generic drugstore berberine to this brand. My digestion improved drastically, gluten-free ingredients are perfect for my dietary sensitivities and overall wellness goals.

      Hannah Cooper

    • Perimenopause cortisol surges ruined my rest completely. After six weeks taking these tablets, nighttime tension fades and I enjoy consistent deep sleep again.

      Nancy Foster

    • I value transparent supplement brands most. This berberine delivers steady energy without crashes, pure formulation works beautifully for my long-term metabolic health maintenance.

      Claire Peterson

    • I avoided harsh sleep aids for years. This herbal blend stabilizes my stress response softly, no side effects, steady energy and calmness throughout busy days.

      Ryan Cooper

    • Daily use keeps my lipid levels within healthy ranges. Each batch undergoes full lab checks, the small capsules are effortless to take alongside my morning vitamins each day.

      Eric Sullivan

      • My doctor recommended this to manage stress hormone imbalance. It curbs afternoon stress slumps and eliminates midnight awakenings reliably for me.

        Paul Gardner

      • This supplement balanced my cortisol perfectly.Ifallasleep faster now, daytime anxiety faded away totally, totally worth continuous purchase.

        Michelle M.

      • Switched from generic drugstore berberine to this brand. My digestion improved drastically, gluten-free ingredients are perfect for my dietary sensitivities and overall wellness goals.

        Hannah Cooper

      • Perimenopause cortisol surges ruined my rest completely. After six weeks taking these tablets, nighttime tension fades and I enjoy consistent deep sleep again.

        Nancy Foster

      • I value transparent supplement brands most. This berberine delivers steady energy without crashes, pure formulation works beautifully for my long-term metabolic health maintenance.

        Claire Peterson

      • I avoided harsh sleep aids for years. This herbal blend stabilizes my stress response softly, no side effects, steady energy and calmness throughout busy days.

        Ryan Cooper

      • Daily use keeps my lipid levels within healthy ranges. Each batch undergoes full lab checks, the small capsules are effortless to take alongside my morning vitamins each day.

        Eric Sullivan

        FAQs

        Are your supplements FDA approved?

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        What type of quality procedures do you follow?

        We invest in cutting-edge equipment and manufacturing controls to ensure the safety of products and employees. This includes controlled security card access, temperatures, humidity and air pressure controls, HEPA filtration, and defined operation rooms to prevent cross-contamination. Our ingredient and product testing process is rigorous - including identity (each ingredient is exactly what it claims to be), safety (heavy metal, pesticide, aflatoxins, microbial and impurity testing), potency (dosing remains true from the point of manufacture, through to expiration), and bioavailability (how the ingredients are released and absorbed - which means you derive the benefits). These are critical components to delivering consistent benefits and results.

        Do I need a prescription to purchase these products?

        No, a prescription is not required.

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        Can I take these supplements if I am pregnant, nursing, or on medication?

        We recommend consuting your heathcare providerbefore using any supplemen, especialy fyou are pregnan, nursing, taking medication, ormanaging a medicalcondition